Jaymee Carnes led the eighth-ranked Red Elephants (15-4, 5-0 Region 7B-AAA) with 16 points and 11 rebounds in the win.
Kiki Thompson also had nine points for Gainesville, while Taylor Ricketts, Madison Strickland and Loren Thomas each scored eight points.
West Forsyth was led by a team-high eight points from Kelsey Turchi.
The Lady Red Elephants jumped out to a 21-4 first-quarter lead and held a 42-15 advantage at halftime.
Gainesville plays host to Pickens at 7 p.m. Friday.

Gainesville's Madison Strickland, center, shoots over defenders in a game earlier in the season. Strickland scored eight points in the Red Elephants' win on Tuesday night over West Forsyth.
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