clearn.png
Wednesday February 24th, 2021 9:57PM

UK vaccine chief warns of over-optimism, early imperfection

By The Associated Press

LONDON (AP) — Warning that the first COVID-19 vaccines may be imperfect, the head of the U.K effort to develop a vaccine called Wednesday for immediate international cooperation to prevent the “largest global recession in history.’’

U.K. Vaccine Taskforce chair Kate Bingham also warned against over-optimism, saying there is no guarantee a successful vaccine against the novel coronavirus will ever be developed.

“The first generation of vaccines is likely to be imperfect, and we should be prepared that they might not prevent infection, but rather reduce symptoms, and, even then, might not work for everyone or for long,’’ Bingham wrote in an essay published in The Lancet medical journal.

No vaccine has ever been developed against any coronavirus, and numerous attempts to design vaccines against SARS and MERS, two which are related to the virus that causes COVID-19, have failed. Scientists also warn that immunity against coronaviruses appears to fade over time and that achieving any vaccine-induced immunity to protect against infection or severe disease could be challenging.

Bingham’s comments come as government leaders in Britain and other countries are basing their COVID-19 strategies on expectations of a vaccine becoming available as soon as early next year.

Prime Minister Boris Johnson, for example, has implemented a three-tiered regional strategy aimed at slowing the spread of the disease until there is a vaccine while also minimizing the economic damage from another widespread lockdown.

Meanwhile, coronavirus cases, hospitalizations and deaths in the U.K. and elsewhere in Europe are rising amid a second wave of infections.

Britain created the Vaccine Taskforce earlier this year to speed the development of a vaccine. Two candidates are in late stage trials, with results expected around the end of the year or early 2021. Dozens of other potential vaccines are in earlier stages of development.

But Taskforce chair Bingham said the candidates that have progressed the most in testing are based on new approaches with little history of being used in vaccines. Vaccine candidates based on more frequently used methodologies aren’t likely to be ready until late 2021, she added.

In addition, it will be a challenge to rapidly produce enough vaccines to combat the virus. The global manufacturing capacity is “vastly inadequate for the billions of doses that are needed,” she wrote in The Lancet.

“China, Europe, the USA and the U.K. need to work together,’’ Bingham wrote. “If we establish international collaboration right now, then we will be better prepared to control future pandemics without causing the largest global recession in history and the biggest threat to lives in living memory.’’

The World Health Organization says it hopes first-generation coronavirus vaccines will have an efficacy rate of at least 70%, but it has acknowledged that 50% might be more realistic. The European Medicines Agency has not specified any minimum efficacy threshold for COVID-19 vaccines and said they would be evaluated on a case-by-case basis.

___

Maria Cheng contributed to this story.

___

Follow AP pandemic coverage at http://apnews.com/VirusOutbreak and https://apnews.com/UnderstandingtheOutbreak

  • Associated Categories: Associated Press (AP), AP Health, AP Entertainment, AP Business, AP Business - Economy
© Copyright 2021 AccessWDUN.com
All rights reserved. This material may not be published, broadcast, rewritten, or redistributed without permission.
Turkish leaders condemn Charlie Hebdo cartoon of Erdogan
Turkish officials are railing against French satirical magazine Charlie Hebdo over its cover-page cartoon mocking Turkish President Recep Tayyip Erdogan, accusing it of sowing “the seeds of hatred and animosity.”
2:22PM ( 12 minutes ago )
Hospital, residential areas hit in Nagorno-Karabakh fighting
Rockets have hit a hospital and residential areas amid deadly fighting between Armenian and Azerbaijani forces over the separatist region of Nagorno-Karabakh that has raged for more than a month despite a U.S.-brokered cease-fire
2:08PM ( 26 minutes ago )
Tanzania votes but 'widespread irregularities' are claimed
Tanzania’s leading opposition presidential candidate asserts that Wednesday's election saw “widespread irregularities" amid a massive internet slowdown
2:00PM ( 34 minutes ago )
Associated Press (AP)
The Latest: US to buy initial antibody doses from Eli Lilly
The U.S. government has agreed to buy initial doses of an experimental COVID-19 antibody drug from Eli Lilly that patients could receive if federal regulators allow it on an emergency basis
1:09PM ( 1 hour ago )
Germany, France look to more limits to curb rebounding virus
German officials have agreed to impose a four-week partial lockdown and the French government is preparing to announce its own new restrictions as European governments race to stop a fast-rising tide of coronavirus cases
1:07PM ( 1 hour ago )
Lockdowns, business rollbacks threatened amid surging virus
A surge in coronavirus cases is prompting the threat of lockdowns or a return to business restrictions reminiscent of the spring in Europe and some parts of the U.S. French President Emmanuel Macron was set to give a televised address Wednesday as many French doctors urged a new nationwide lockdown, as 58% of the country’s intensive care units are now occupied by COVID patients
12:55PM ( 1 hour ago )
AP Health
Outlaw country artist Billy Joe Shaver dead at 81
Outlaw country singer songwriter Billy Joe Shaver, who penned songs for Waylon Jennings, Willie Nelson and Bobby Bare, has died
1:53PM ( 41 minutes ago )
Russell Wilson, Ciara fund charter school in Seattle area
Football star Russell Wilson and his wife Ciara, the Grammy-winning performer, are the latest wealthy philanthropists to back a charter school
1:43PM ( 51 minutes ago )
Gang member who says he beat up R. Kelly sentenced in deaths
A convicted gang member who says he beat up jailed R&B singer R. Kelly in a Chicago cell has been sentenced to life in prison for a racketeering conviction that involved two 1999 murders
1:32PM ( 1 hour ago )
AP Entertainment
Hurricane Zeta speeds toward a storm-weary Louisiana
Workers have closed one of the last floodgates surrounding New Orleans ahead of landfall by Hurricane Zeta, which is growing stronger as it speeds toward a storm-weary Louisiana
1:48PM ( 46 minutes ago )
Stock rout deepens as S&P 500 drops 3.2%, Dow falls 800
Stocks around the world are tumbling Wednesday on worries the worsening pandemic will mean more restrictions on businesses and drag down the economy
1:37PM ( 57 minutes ago )
Biden vows not to make 'false promises' about pandemic
Joe Biden says he’s “not running on the false promises of being able to end this pandemic by flipping a switch” but would immediately prioritize science
1:34PM ( 1 hour ago )
AP Business
Stock rout deepens as S&P 500 drops 2.5%, Dow down 700
Stocks around the world are tumbling Wednesday on worries the worsening pandemic will mean more restrictions on businesses and drag down the economy
12:05PM ( 2 hours ago )
Stock rout deepens; S&P 500 drops nearly 3%, Dow down 800
Stocks around the world are tumbling Wednesday on worries the worsening pandemic will mean more restrictions on businesses and drag down the economy
11:32AM ( 3 hours ago )
As virus surges, isolated UK leader Johnson faces many foes
British Prime Minister Boris Johnson’ is battling both the coronavirus pandemic and a long list of political foes
11:04AM ( 3 hours ago )
AP Business - Economy
Turkish leaders condemn Charlie Hebdo cartoon of Erdogan
Turkish officials are railing against French satirical magazine Charlie Hebdo over its cover-page cartoon mocking Turkish President Recep Tayyip Erdogan, accusing it of sowing “the seeds of hatred and animosity.”
2:22PM ( 12 minutes ago )
Hospital, residential areas hit in Nagorno-Karabakh fighting
Rockets have hit a hospital and residential areas amid deadly fighting between Armenian and Azerbaijani forces over the separatist region of Nagorno-Karabakh that has raged for more than a month despite a U.S.-brokered cease-fire
2:08PM ( 26 minutes ago )
Tanzania votes but 'widespread irregularities' are claimed
Tanzania’s leading opposition presidential candidate asserts that Wednesday's election saw “widespread irregularities" amid a massive internet slowdown
2:00PM ( 34 minutes ago )
Europe and US facing new round of shutdowns amid virus surge
Germany on Wednesday moved to shut down restaurants, bars and theaters all over again and France weighed demands for another nationwide lockdown as an alarming surge in coronavirus infections in Europe and the U.S. wipes out months of progress against the scourge on two continents
1:57PM ( 37 minutes ago )
AP sources: Morey in advanced talks to lead 76ers
The Philadelphia 76ers are in advanced negotiations with former Houston Rockets general manager Daryl Morey to become their president of basketball operations, according to multiple people with direct knowledge of the negotiations
1:57PM ( 37 minutes ago )