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Sunday September 22nd, 2019 8:38AM

OncoCell Announces Late-Breaking Poster Presentation at AACR 2019 on a Noninvasive Blood-Based Assay for Prostate Cancer Prognosis

By The Associated Press

ATLANTA--(BUSINESS WIRE)--Apr 1, 2019--OncoCell MDx, a company developing novel noninvasive diagnostic and prognostic tests, will present results from a feasibility study of a new prostate cancer prognostic assay in a late-breaking poster session at the tomorrow. The study demonstrates that the blood-based immunogenomics RNA expression assay provides a prognostic summary comparable to that of prostate biopsy.

OncoCell’s Subtraction-Normalized Expression of Phagocytes (SNEP) based platform, invented by Professor Amin Kassis, while at Harvard Medical School, uses a proprietary algorithm to interrogate changes in gene expression of two immune cell types consequent to prostate cancer including phagocytic (CD14) and non-phagocytic (CD2) cells, filters out intrinsic genomic variation not related to the disease, and identifies and validates prostate cancer-specific signatures. A study of blood samples from 713 prostate cancer patients showed the platform provides a prognostic summary including tumor Gleason grade distribution, size/volume and heterogeneity that is comparable to prostate biopsy information, and that it stratifies patients with aggressive disease that need life-saving treatment from those with indolent disease.

In the study, CD2 and CD14 cells were isolated from peripheral blood samples and mRNA samples were extracted and sequenced from each cell type. Transcripts with quantifiable expression changes were used to train OncoCell’s proprietary SNEP-based algorithm to stratify the patients into those who need treatment versus surveillance. A genomic signature was identified that is predictive of Gleason grade, cores positive and maximum involvement. Signature scores were significantly associated with these endpoints and an Aggressiveness Index that incorporates the three endpoints. Samples from two independent sets of naïve patients (n=305 and n=470) validated the results.

“We are encouraged by the results of these study findings, which suggest this assay may play an important role in advancing clinical management of prostate cancer patients,” said Philip Kantoff, M.D., Clinical Advisor to OncoCell and Chair of the Department of Medicine, Memorial Sloan Kettering Cancer Center.

Details of the study are being presented April 2 from 1:00 p.m. to 5:00 p.m. EDT in a poster session titled “ ( ) at the Georgia World Congress Center, Exhibit Hall B, Poster Section 41, Poster Board Number 19.

The poster will be made available on the company’s website at .

OncoCell MDx is a privately held company developing and commercializing novel diagnostic tests utilizing proprietary technologies created at Harvard Medical School. The company’s noninvasive blood-based immunogenomic assays are designed to aid physicians to better understand underlying disease pathology in prostate cancer and other oncology and non-oncology indications.

View source version on businesswire.com:

CONTACT: Press Contact:

Virginia Amann for OncoCell MDx

VirginiaAmann@ENTENTEInc.com

+1.608.207.0082

KEYWORD: UNITED STATES NORTH AMERICA GEORGIA ILLINOIS

INDUSTRY KEYWORD: HEALTH BIOTECHNOLOGY CLINICAL TRIALS GENETICS MEDICAL DEVICES ONCOLOGY RADIOLOGY OTHER HEALTH RESEARCH OTHER SCIENCE SCIENCE

SOURCE: OncoCell MDx

Copyright Business Wire 2019.

PUB: 04/01/2019 02:28 PM/DISC: 04/01/2019 02:28 PM

http://www.businesswire.com/news/home/20190401005782/en

  • Associated Categories: Associated Press (AP), AP Health, AP Business, AP Online - Georgia News, AP Business Wire - Georgia, AP Health - Men's Health, AP Business - Industries, AP Business - Health Care
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